" Herb Kinsman got the axe." " So who's in charge?" "A guy named Carl Riddlemeyer." "How'd did you get this appointment without knowing one thing about science?" "Well, I slept with you for 25 years." "Why the heck do I need NorBAC?" "Science is on the verge of unlocking the secrets of life." "And you're thinking about amputating the only organization that's actually minding the store!" "You're insane!" " I'm gonna do this thing with Angie." " Who?" "Angelica Starov." "I'd like to talk to you about Owen." "She fixes addicts by messing with the biology in their brains." "Owen, the science is way off." "We have 4 hospitals saying it's" "West Nile and 3 saying it isn't." "3 of the sick people paid for a night at the same motel on the same night." " The floor was rented for a convention." " What kind of convention?" "How many partners do people have in a night?" "I don't know, 1, 10, 20." "It's up to them." "We just got a priority alert of an outbreak in Boston." "13 thirty-somethings, male and female, in critical condition, 1 fatality." "This little virus is already starting to jump cities and we still don't know what it is!" "We're losing!" "Fever, headaches, stiffness, convulsions, pneumonia, coma." "Identical to San Francisco." " Any success with treatment?" " None." "Dr. Farlow, do any of the patients know each other?" "Only the ones who are married, and I give them the benefit of the doubt." "It's spread out over the western inner suburbs of Boston." " From Watertown and south to Newton." " Where's that?" "Get a map." "No one has been to San Francisco recently." "No one will admit to belonging to a swingers club." "Except me." "Doctor, can you look at this?" "There's been a change in the condition." "No elderly." "No children." "Overall, they skew a little younger than San Francisco." "More women than men too." "Divide and conquer?" "What were the first symptoms?" "Is your husband sick?" "Your children?" " How old are they?" " What do you do for a living?" "Moms." "Dads." "No one had little kids in San Francisco." "I think that's the common link here in Boston." "These people aren't swingers." "They push swings." "Maybe..." "That's a pretty wide net." " How many of them have children?" " Don't know." " Just the baby?" "How old?" " Almost one." " She was sick first?" " Yeah." "Do you have a nanny?" "A babysitter?" "Where have you been with her in the last 2 weeks?" "Sorry, what's Kiddie Joyland?" "Do you ever go to a place called Kiddie Joyland at the Maple Creek Mall?" "You were there last Monday?" "It could be a coincidence." "Babies are always sick." "But Kiddie Joyland, that's not a coincidence." "ReGenesis 3x04 I Dream of Genomes" "Subtitles Team NorBAC" "Synchro Bbsiocnarf, Golgi, Goufrach, Lovechange, NikoMagnus" "Version NoTag 1.0" "Nothing to do with me." "13 people are very sick." "Their babies were all here last week." " I wash the toys." " Do you disinfect using bleach?" "In the future, please do." " How long are you closing me?" " You didn't notice if anyone was ill?" "I need a receipt for everything he takes." "Fine, we'll get you a receipt." "Now answer my question." "Did you see if anyone was very sick?" "Why don't you answer my question?" "How long are you closing me?" "50 years if you don't answer my question." "What?" "Go to hell." "David." " What?" " What's with you?" "I hate foreigners." "Especially you these days." "Why isn't she sick?" "That's a good question." "By any chance, are you on Interferon?" "I don't know what you're talking about." "How are you feeling?" "Do you have any cold or flu symptoms?" " No." " Are you on medication?" "No." "Should we take her in for a blood test?" "How many kids are here on a weekday?" " 200." " 200!" "You deal with 200 kids a day?" "By yourself?" "Remember those 50 years you're gonna be closed?" "I have help..." "One girl." "Who?" "Look, we don't care if she's illegal." "Katarina." "I can't pronounce her last name." "From Bratislava." "Is she sick?" " How sick?" "Is it a flu?" " How long has she been sick ?" "I don't know." "She hasn't been here all week." "Listen, Owen, I read some of Angelica Starov's papers and yes, she's doing amazing stuff, but let's hold off till she's nailed the science." "Okay?" "She's still working with mice, for Christ's sakes." " I can't wait." " Yes, you can." "When I was your age I thought waiting till the weekend was a lifetime, but it's not." "Hang on a second, Owen." " What?" " We're ready for you." "Okay, hang on." "Carlos!" "They're ready." "Listen, I gotta call you back." "I'll call you tomorrow." "When I met you, you were living in a refrigerator box in the subway." "I think you can hold out there for a little while longer." "The guards are sick." "Black dudes won't even talk to me." "I'm supposed to hang out with the white guys, but they're all fucking Nazis." "Finally fucking got me, okay." "They held me down, and took turns." "Owen, I'm sorry." "But listen, there's a virus." "People are dying." "I've gotta go." "Wes, I'll put you on speaker." "The police and medical investigators seem to know what they need to do, which is find out how Katarina got infected and who she came into contact with." "Wes, the Boston patients are all parents of infants." "Not sure yet if the adults are making their babies sick or the other way, but outbreak seems to be centered around a place in a mall where kids play." "Kiddie Joyland." "The key here is that the babies all recover." "No deaths or hospitalizations?" "With the babies, none." " Why?" " We don't know." "Logan Airport." "The guy in San Francisco who isn't very sick with Sinatra." "He has Chronic Granulomatous disease?" " Yeah." " Find anything out about the fatality in Boston?" "Early 20s." "She worked at Joyland." "Died about 18 hours ago." "I'll see what else I can dig up about her." "We have no proof it was Sinatra, but it's a pretty good bet." "So we're making that assumption." " Any connection to San Francisco?" " The police go through her apartment." " Wait, wait, wait..." " Bob." "Remember when I thought it had something to do with the 4 genes associated with Chronic Granulomatous Disease?" " Yeah." " CYB-B, CYB-A, NCF-1 and NCF-2." " It doesn't." " Bob!" "What do babies and people with Chronic Granulomatous Disease have in common?" "Nice catch, Bob!" "Of course." "They both have weak immune systems." "What's going on, guys?" "Sinatra is one of those diseases where technically it's not the disease that kills you:" "it's the immune system's response to it." "Your body is trying so hard to kill the germs, it literally kills itself." "Yeah, but if your immune system is weak like in babies, it's not strong enough to kill you." "Which explains where we went wrong in San Francisco." "Pete Braungart's immune system was low so he was on Interferon to boost it." "And we thought the Interferon was what was fighting off Sinatra." "When we gave Nina Interferon, her immune system became hyperactive, and it killed her." "I made a mistake, David." "If it makes you feel any better, we all blew it." "Shit!" "Call an ambulance!" "Sign in." " I don't remember having lunch." " Yeah, we didn't." " It's too late now." " Yeah." "What?" "Yeah." "I gotta go!" " Bob." " Hi, Carlos." "Hey." "Toys from Joyland." "If you could take half for toxicology, the other half for virology and bacteriology." " I'll sort it." " Thank you." "You try to commit suicide again, I'll kill you." "Nice." "Well, congratulations, you're out of juvenile detention." "Your words, Owen." "Use your words." "I know your throat hurts but your tongue still works." "Alright, suit yourself." " Rachel." " Hey." " I have babies blood." " Thanks." "You think they survived Sinatra?" "You tell me." "Alright." "Where are you, Sinatra?" "Down to scraping the bottom of a duck, are we?" "Last of all the toys." "You know, Queen Elizabeth has a rubber duck with a crown in her bathtub." "I don't know why I know that, but I do." "Have you found anything yet?" "Lots of common bacteria plenty of viruses, nothing identified yet." "That might be about to change." "I have some interesting interim results." "So, of the 73 viruses we found in patients 7 and 9 from San Francisco, 13 didn't occur in the control group." "Let's compare those 13 viruses to the blood work from Boston." "See if we can't isolate one common virus." "Alright. 13." "Maybe it's our lucky number." "While you're at it, why don't you check it against her majesty's fowl there." "Maybe we can tie the virus into the babies somehow." "Whose fowl?" "Oh, just send me the results." "Alright..." "My guilt only keeps me here so long." "Bye." " Fuck you." " Ah, he speaks!" " Talk to me." " I asked you to help me." "Yeah, I cannot stay in here!" "You told me that my addiction could be fixed." "Now you tell me that it can't." "What the hell am I supposed to think?" "!" "What I told you was we might be able to turn off the addiction genes in you." "But the science is, like, 15 years from now." "Angelica can do it now." "I don't know what she's proposing, but I doubt it's what I had in mind." "Look, I just asked you to talk to her." "What I think, is that Angelica Starov is in a rush to prove herself by pushing forward something that hasn't been fully tested." "It's gotta be tested some time, so why not on me?" "Because I don't want you as the first kid on your cellblock to get a brain fuck from a scientist!" "You're such a hypocrite." "You'd test stuff on yourself, wouldn't you?" "That's, that's entirely different." "How?" "Because I know how stupid something like this is." "I'm just as stupid as you are." "I'll talk to her." "Talk." "Mommy." "So you know, I'm just about to say to her, come on, just relax, kids, they need their viruses and their bacterium in order to develop their immunity." "And then it hit me." "Sinatra must be a disease like measles or mumps or chickenpox." "Sorry, I don't get the connection." "With Sinatra, children survive." "It's like the mumps." "It's relatively harmless in children, but in adults the symptoms can be quite severe," " leading to infertility." " Exactly." "See." "What I'm thinking is..." "All this time we have been looking for a rare disease." "But Sinatra is not a rare disease." "I mean, it's rare here in North America." "But somewhere out there in the world it's a very common disease." "It's so common that every baby is exposed to it." "And babies live because they don't launch much of an immune response." "A weak immune response saves them." "And as adults if they get the disease, they've got antibodies so they don't get as sick." "Okay, but bring Sinatra to North America where we don't get it as kids and then we're like those natives." " Adults just start dropping like flies." " But not babies." " That's got to be it." " Maybe." "Let's hope so." "Okay, what have you got?" "Oh, the Boston victims you gave me?" "None of them links to San Francisco." "Okay, so we still have no idea how it's crossed the continent." "We have one virus in 2 of the San Francisco patients, 3 of the Boston babies, and not in our control group." " We think we have our guy." " Fantastic!" "We're still checking toys to see if we can find it, then we can figure out how it spread." " I'll run it against the databases." " We're on our way, and so am I." "Let me help you with that." "Thank you." "Go to work." "Thank you." "Excuse me." "Angelica Starov?" "She's right over there." " Dr. Starov." " Angelica." " And you are David Sandström." " I am." "Good to meet you." "So you do want to learn how I can help Owen?" "I do." "Let's get out of here." "Quick dinner, maybe?" "Pizza?" "I was just thinking about having some pizza." "Let's go." "He's a desperate kid." "I can't believe he tried to kill himself." "Me neither." "At least he's okay." "Well, kinda." "David, I really like Owen." "He's gutsy." "He has his charms." "I was really upset when they put him in Violent and Dangerous wing." "I've spent time there." "Really?" "As a scientist." "It's not pretty." "Let's talk science." "Well, um..." "I've been working on the chemistry of addiction since I was an undergrad." "Did my post-doc on it." "Do I look familiar?" "For the whole year of proteomics" "I sat in the front row and smiled at you." " Oh, now I remember." " Sure you do." "Well, there were 20 of us, actually." "Staring at you." "When was this?" "Maybe 8 years ago." "See, there's a lotta beer under the bridge." "I hated teaching." "That much we learned!" "I love teaching." " What have you got?" " The micro array results for Sinatra." "5 of the samples overlap for herpes virus, nothing else though." " Could it be beta?" " Maybe." "Not definitive." "I'd need more sequence results." "Well, I've got a guy over at U of T sitting on his ass waiting for this." "I still remember that lecture like it was yesterday." "Even then, you were talking about genetics and addiction." "I still think it's the only solution." "But I don't think we're there yet." "I am." "What do you know about Switch Theory?" "It's like doing heroin." "The heroin causes your nerve cells to release a neurotransmitter called Gaba, which makes you calm." "But if you do too much heroin, your nerve cells' neurons overload and malfunction." "The malfunction triggers a neighbouring neurotransmitter that does the opposite." "Instead of Gaba, you get dopamine, which energizes you." "It gets you, gets you up, speed up, twitch." "You get obsessive." "You crave that hit again and again, and hence, addiction." "All we have to do to stop the addiction is throw back the switch." "Well, yeah, but how are you going to do that?" "Well, when you become an addict, it's because your brain chemistry has changed." "So I'm going to change that chemistry back." "How?" "That's a secret." "And to get an answer, you're going to have to buy me dinner." "Because this one is on me." "Thank you." "Thank you." "Tomorrow." "Let me check my date book." "I'll call you." "Hey, Rachel, results." " Hey." " Alright, what have we got?" "The viral sequence is identical look." "It's 100% match." "To a Beta Herpes virus?" "What about other primer sets?" " No, there's nothing." " Controls?" "Controls are negative." "Oh my god." "Well, this could be our guy." "Yeah." "Okay, what is it?" "I don't know." "Let's send it to TIGR." "Sequence the genome from all 5 samples." "Yeah, but people are gonna die waiting." "Screw it, you know, I'm gonna do an ELISA." "That won't be sensitive enough." "Oh yeah?" "Watch and learn." "Rachel." "You're snoring." "What?" "Sorry, I was..." "We were just trying to get in touch with you." "Was I really snoring, really?" " So, ya got good news?" " No." "It's great news!" "Sinatra is Filipino Virus C-2." " You sequence it?" " Yep." "Does it look like anybody fucked with it?" "You familiar with it?" " It was a big killer in the 80s, right?" " That's right." "At its peak, it was killing about 20 Westerners a month." " How'd they get rid of it then?" " They didn't." "After 6 months, it died out, before they were anywhere near a cure." "Shit." "Okay, go home get some sleep." " Really?" " Really." "Okay." "Good work, Rachel." "Here it is." "Sinatra a.k.a Filipino virus C-2." "It's related to chicken pox and mono, maybe cancer and MS." "Really?" "Here's the genome." "Typical beta herpes virus." "Icosahedral capsid envelope non-structural proteins, linear double-stranded DNA." "And David was right." "It is common somewhere else as the name may suggest, in the Philippines." "What exactly does that mean?" "Babies get it but because it's the response that kills and babies can't mount much of an immune response, they live." "Aw shit!" "That's why the Filipino woman in Boston didn't get it." "She had it as a kid." "Staring us right in the face." "I'll inform the hospitals in Boston and San Francisco." "They'll have some idea what they're dealing with." " Should I include the CDC?" " Of course." "Okay, Wes." "You and Mayko, you're with me." "Patient Zero." "I wanna find out how this thing ended up in Boston and San Francisco." "Bob, Rachel, Carlos;" "cure and treatment." "Let's go." "Okay first thing we need to find out:" "How many people fly from the Philippines to the USA everyday?" "4000 on average." " How do you know that?" " I googled it." "I told you he's not a complete idiot." "Second, we need to find out who the hell flew from the Philippines to the USA between 3 and 5 weeks ago." "I'll triangulate Boston, San Francisco, and the names on passenger manifests." "Good." "Trouble is we still don't know everyone who's in the Sinatra Appreciation Society." " I'm working on it." " Good." "Wes, I need you to get Homeland Security to crack that Sinatra guy's computer." "Anything about Boston or the Philippines." "Now, what about that Slovakian co-worker?" "Katarina." "She's illegal." "All her friends are illegal." "Nobody's talking." "Wes, maybe she brought Sinatra to North America." "Maybe she connects to San Francisco." "Maybe she fucked a members of the club." "Well, shit, Wes." "Pull some strings." "Or yank some chains." "Use whatever cliché you want, but find out how she got it." "Bob, Rachel, Carlos;" "cure and treatment." "Let's go." "Alright." "Okay, we need to find out what, if anything, they learned from when it hit in the 1980s." "Tufts is coordinating a number of studies on historical rare beta herpes outbreaks." " I can call them." " I'll find what they do in Philippines." "Maybe, they've established some kind of protocols for dealing with adult foreigners who get the disease." "Maybe there's an outbreak right now." "I should get in touch with WHO and see if there's an outbreak of C-2 anywhere else in the world." "What other bases can we cover?" "Well, if I could get a virus off that rubber duck, we could confirm that Joyland was the centre of the outbreak." "How's it going?" "Lots to do." "Got 2 minutes?" "I found some scientists out of Barcelona using viral vectors as a transport system to knock out cancer." "They're in stage one clinical trials." "I need you to look into it, okay?" "Give them a call, find out how the trials are doing." "I've got some specific questions here about applying it in gene therapy." "What's this about?" "Personal favour." "That addiction gene theory of mine." "I just, I figure maybe in Spanish you'll get a better idea of how good their science is." "Okay." "I'll call them as soon as I familiarize myself." "Okay, thanks." "But Sinatra has priority." "Of course." " This enough?" " 2 more." "So, tell me your secret recipe for erasing Owen's addiction." "Don't you believe in conversational foreplay?" "Figures." "Come on, I told him I'd get on it." "I want to go after the dopamine pathway." "Yeah, you and everybody else." "With a genetic cure." "How?" "Insert a protein that inhibits dopamine beta-hydroxylase right in the addiction part of the brain." "I do it once and his genes do the work forever." "You got it happening?" "In mice, right?" "Yeah." "Well, it's pretty easy to inject it in a mouse brain." "How you gonna do it in a human?" "Come on." "This is show and tell." "We've done it with primates." "Tell me more." "Ventral tegmental area of the midbrain." "Intersection of... these 2 lines." "How do you get it in there?" "A crippled alpha herpes virus." "They love to hide out in your nerve cells, so we hop aboard for a ride." "It travels along your optic nerve to the optic chiasm." " Where the nerves of the eyes cross." " Right there, is a part of your optic nerve that goes up into a ventral tegmental midbrain." "Pretty easy." "In theory." "What if I told you somebody's already working on it?" "Who?" "!" "When I was in China, the virologist there said that they were using a crippled alpha herpes virus to deliver agents to knock out genes in the brain." " Which genes?" " The ones for violence and aggression." "I mean, they got 1.5 million people in jail." "They want to give them all injections and send them home." "The US has 2 million in jail." "Costs the taxpayer 200 billion a year." "Which is probably why they never turn me down for a grant." "So, how are the Chinese doing?" "Well, they keep shutting down the wrong genes and killing people." "Well, I guess this is one department where we're ahead of them." "In my lab we developed a new way to regulate viral latency." "We can deliver viruses right... to the nerve cells." "You're not a bad cook." "Thank you." "What else can you do?" "Oh, not much." "Just the 3 Ss." "And those are?" "Science, steak and..." "And?" "Isn't, uh..." "Isn't appetite related to the same... neurological" " pathway as addiction?" " Yeah." "Well, what if your cure accidentally cures him from eating?" "Yeah, it did... in rhesus monkeys." "But... people know they have to eat." "He's a kid." "If he thinks he can save money on food so he can buy tickets to Phish, he will." "Phish?" "They broke up in 2004." "Wait, wait, stop." "If you take away his addiction, that means he can never become addicted." "And if he can never become an addict, what's to keep him from doing all the drugs he wants to do?" "3 reasons: cost, overdose and risks associated with needle use." "No, no..." "He'll think he can quit when he wants and then he's gonna die of AIDS or Hep C or an overdose." "People take risks everyday." "At least it will be his free choice." " Yeah, but..." " Now please shut up." "A genetic cure is permanent." "Why don't we try something temporary like a carbonic anhydrase inhibitor." "That'd work." " Want some ice cream?" " Sure." "He would have to take a cure every day." "So?" "A lot of people take meds every day." "We are talking about drug addicts, marginal people, the homeless, kids." "You want chocolate or chocolate?" "Chocolate." "David, you argued at his bail hearing that genetics have to be considered in court." "Fine, but society can go 2 ways." "If we say that addiction is genetic, then the public will demand that we will lock them up forever or cure them." "How about... a bowl or at least a spoon?" "I hate using dishes." " On the table?" " We're not animals." "I'm not the first, am I?" "I love my kitchen." "So come on." "Let's go with a carbonic anhydrase inhibitor." "I mean, it'll tell us how likely a permanent cure would work." " David." "Good morning." " Morning." "So I went through everything." "I spoke with a Luis Arroyo in Barcelona." "Very helpful, doing exceptional work there." "He sent me his latest results." "Now, this in particular I think might be of interest to you." " Okay, Thanks Carlos." " Is this about Owen?" "Because Arroyo said if you try this on a human being, you should be arrested." "It's okay though, 'cause Owen's just a teenager." "I'm joking." "We're gonna go with carbonic anhydrase inhibitor, see what that does." " Okay?" " Okay." "Thanks for this, though." "Morning." "What's with you?" "Did you join a cult?" "Just happy to be alive." " You join a cult." " No!" "But there was a guy from the Sinatra Society who traveled to the Philippines." " Tell me." " Mark Smith, with a "k"." " And he bought a ticket to Boston." " Fuckin' A. Congratulations." "Beauty beat the Beast." "Wes!" "Find Mark Smith before he infects the whole goddamn continent." "I'm already on it." "When did he get so..." "Efficient?" " How'd you get the name?" " I didn't." "Wes did." "Well remind me to apologize to Wes at the Christmas party." "Hey, what Christm..." " Alright, explain it back to us." " I'm not an idiot." " Pretend I am." " Easy." "You're gonna give me a shot every day." "Then that's gonna cure of my addiction." "And then I can go petition the courts to be released." " The risks of dosage?" " I didn't catch that part." "It's a glaucoma medication." "This is off-label." "That means we're using it for something it wasn't designed to do." " And at the higher dosage." " Who cares?" "Fear of risky behaviour is not in his genes." " But you're gonna cure me of all that." " No." "The genes that make you a risk for addiction are still gonna be there." "We're gonna try to undo what they've done to your body chemistry." "Then it's back to free will, kiddo." " Can you turn down drugs?" " Of course." " Owen, you're doing crystal again." " I can kick!" " Can you give us a minute, please?" " Sure." "Okay, I'm gonna tell you something." "I've got the same genetic predisposition for addiction as you do." " Fuck you." " Pretty much." "And I went right off the rails a little while ago." "And I had to give up drinking period." "This is gonna be the hardest thing you've ever done." "Good luck." "San Francisco's reporting 5 new cases." "As far as we can tell, they're connected to the Sinatra Appreciation Society." " Any new fatalities?" " 2." " Recoveries?" " Still none." " What about Boston?" " 3 new cases." "No new fatalities." " Where are we with the antivirals?" " I've started testing." "4 hospitals are trying various cocktails." "I guess we're gonna have to get imaginative." "In the Philippines, babies get it." "They have immunity from breast milk, they often don't have bad infections." "There's a treatment we haven't tried." "How do you treat non-Filipinos who get it?" "Nothing works." "Fortunately, surprisingly few North Americans get infected with C-2." "But if adults do, they usually die." "Effective way of keeping it from spreading here ?" "There are no C-2 outbreaks in the world, including the Philippines." "Bob, what about that outbreak in the early 80s in the US?" "An American soldier brought it back." "He had relations with a prostitute who had a young baby." "Most likely, he contracted it from the baby." "I've confirmed Sinatra in Boston blood samples from the babies, and I also found it on several toys from Joyland." "There it is." "We're officially dealing with 2 outbreaks." "Spread through swingers' club in San Francisco, how's it spreading in Boston?" "Scenarios." "A baby has Sinatra." "They spread it to other babies and the parents get sick." "Something else." "A parent contracts disease, they give it to their baby, who spreads it to other." " And their parents in turn contract it." " Closer." "How about this?" "Katarina was one of the first to die." "Maybe she was in fact the first infected." "She goes to work sick, handles the toys." "Babies get the disease pass it to one another, give it to their parents." "Dollars to donuts that's how it went down." "We have to check the other scenarios." "But I mean it kind of fits, you got an early death;" "you got a connection to Kiddie Joyland." "My gut tells me there's something there." "How did it jump cities?" "Where are we at with Mark Smith?" "It's one of the most popular first and last names in America." " You could fill city with Mark Smiths." " We only need one, Wes." " Hey." " Hi there, Dr. Starov." "Why don't you join me in my office?" "... on "Ibogaine signals in addiction"." " What was that all about?" " He's a fan." "Easy." "That's not why I'm here." "Owen has massive amounts of blood in his urine and his stool." "Shit." "Apparently it's a common side effect, but not at these amounts." "Let's lower the dosage." "The IRB protocol physician insists we take him off the drug." "I have no choice." "We'll appeal it." "It will take 6 months, David." "With the gene therapy, there won't be any internal hemorrhaging." "Why are we even discussing it?" "The IRB gave me the go-ahead." "So did Owen." "Do you know Luis Arroyo from Barcelona?" "Because he says this can't and should not be used on a human being." "He would say that." "He's a year behind us." " I want to talk to Owen." " Absolutely." "I told him I wouldn't do it until you had spoken to him." " As a courtesy." " Thank you." "What?" "Excuse me." "I spoke to the police in San Francisco." "Mark Smith was on his way to the airport to fly to Boston." " He didn't make it." " Okay..." "He was killed in a car accident 3 weeks ago." " What?" " Mark Smith did not bring it to Boston." "He's the fucking key." "He's gotta be." "I will take a look at that body if it's still around, so book Carlos and me on the next flight to San Francisco." "You're not doing the gene therapy, period." "You're way out of your depth." "I'm not your student anymore, David." "He was in a head-on with a brick wall." "A car went off the road and the car behind him that was following his lights smashed into him." "We're looking for a viral infection." "Then you want to look at his lungs." "How long has he been here?" "19 days." "No next of kin." " Lungs look healthy." " Very healthy." "So, you guys, you're talking about fatal pneumonia, right?" "Right." "Well, necrotized lungs, you know, they're like burnt hamburger." "I mean, this guy, he's, he's not sick." "No, he's just dead." "A guy with a rare genetic disorder has a mild Sinatra infection because he's on Interferon." "What if Mark Smith here had a mild infection?" "How could we detect it?" "Come on, guys." "Beta Herpes viruses have reputation for hiding out in our cells." "How could we find it?" "Typhoid likes to hide out in the gallbladder, right?" "Right." "I gotta take this." "Hang on." "What about PCR?" "Ok?" "Every organ." "Scattershot." "Go ahead." "He won't give up on this." "We'll take everything, every organ." "See if we can't find where this virus is hiding." "Okay." "It's popped up in Tallahassee." "4 dead, 11 critical." "We know this guy didn't make it to Tallahassee." "Wes is booking us flights to Florida?" "No, we're not gonna catch this thing by chasing its tail." "We've got the beginnings of a pandemic here and we don't have a fucking clue." "What are we missing?" "What do we need to do differently?" " What?" " You wanted me to call you." "Owen, yeah." "I'll catch up." "Listen, Owen, you can't do this procedure." "It's totally untried." "Columbus didn't know where he was going, but he went." "Columbus?" "First of all, Columbus was trying to get to China and he never got there." "Secondly, he could always turn back." "This is irreversible." "Yeah but immediate." " You're not doing it." " I am so." "No I won't allow it." "You're just a kid." "I'm 17." "You'd be jumping off a cliff, Owen." "I can do what I want." "Tallahassee. 6 dead, 16 sick." "3 new fatalities in Boston, 5 in San Francisco." "We're sending you blood and tissue samples from Mark Smith." "The Philippine immigration says Mark Smith never registered in a hotel." "So what was he doing there?" "That is everything you didn't want to talk about." " It's a perfectible procedure." " Fine!" "Perfect it on lab rats!" "Owen is a human being." "I'm training for Muskoka Ironman, right." "I thought it might be fun to go for a ride after work together." "I'm here in Washington with Doctor Joanna Sevine, regional case officer for the centres for disease control." "We're testing 20 birds for avian flu." "Hi." "Sorry am I interrupting?" " This is Joanna, an old friend of mine." " How well do you know her?" "No." "Don't even think about it." "The birds and the people are still sick." "If it's not avian flu what is it?" " Could it be environmental?" " Methylmercury." "They've never seen concentrations like this." "They're off the dial."